UpToDate and the Evidence

Last June we highlighted new features UpToDate had added to support evidence-based practice (see previous post).

Since then some users have wondered how UpToDate develops its recomendations. UpToDate’s experts grade their recommendations with a two part score (i.e. Grade 1B).  The number represents the strength of the recommendation (1=strong, 2=weak). The letter score is the strength of the evidence (A=high, B=moderate, C=low) graded on such factors as the risk of bias, precision of estimates, the consistency of the results, and the directness of the evidence.

For more information about the grading of evidence for UpToDate visit their Grading Guide.


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